????? ????? ? ????? ??? ???????????? ?? ???? ?????? ?????? ? ?????? ???? ???? (?) 1376-1374

author

Abstract:

This article doesn't have abstract

Upgrade to premium to download articles

Already have an account?login

similar resources

Bio012088 1376..1386

The Wnt/β-catenin pathway is implicated in left-right (LR) axis determination; however, the underlying mechanism remains elusive. Prompted by our recent discovery that Wnt signaling regulates ciliogenesis in the zebrafish Kupffer’s vesicle (KV) via Foxj1a, a ciliogenic transcription factor, we decided to elucidate functions of Foxj1a in Wnt-regulated LR pattern formation. We showed that targete...

full text

Dev118968 1368..1374

Live imaging of transcription and RNA dynamics has been successful in cultured cells and tissues of vertebrates but is challenging to accomplish in vivo. The zebrafish offers important advantages to study these processes – optical transparency during embryogenesis, genetic tractability and rapid development. Therefore, to study transcription and RNA dynamics in an intact vertebrate organism, we...

full text

Dmd050542 1367..1374

In the 2012 Food and Drug Administration (FDA) draft guidance on drug-drug interactions (DDIs), a new molecular entity that inhibits Pglycoprotein (P-gp) may need a clinical DDI study with a P-gp substrate such as digoxin when themaximum concentration of inhibitor at steady state divided by IC50 ([I1]/IC50) is ‡0.1 or concentration of inhibitor based on highest approved dose dissolved in 250 ml...

full text

No 1374 October 2015 Crime , Compulsory Schooling Laws and Education

Do compulsory schooling laws reduce crime? Previous evidence for the U.S. from the 1960s and 1970s suggests they do, primarily working through their effect on educational attainment to generate a causal impact on crime. In this paper, we consider whether more recent experience replicates this. There are two key findings. First, there is a strong and consistent negative effect on crime from stri...

full text